A research team led by Louis Vermeulen from the AMC and Prof. Peter Sloot from the Science Faculty of the UvA revealed how recently discovered Cancer Stem Cells play a crucial role in fundamental properties of tumors. In the latest issue of the renowned Cancer Research journal of the American Association for Cancer Research, a multidisciplinary group of researchers report on novel insights on invasive growth and failure of current anti-cancer therapies. (Cancer Research: Vol 70, no 1: 46-56; http://cancerres.aacrjournals.org/cgi/content/abstract/70/1/46 ). A research team led by Louis Vermeulen from the AMC and Prof. Peter Sloot from the Science Faculty of the UvA revealed how recently discovered Cancer Stem Cells play a crucial role in fundamental properties of tumors. Through the use of novel computational models and laboratory experiments they showed how tumor growth, driven by cancer stem cells, intrinsically orchestrates tumor invasion and increased heterogeneity. The research delivers important insights in therapy response of malignancies to current anticancer therapies and has crucial consequences for the development of successful novel cancer treatments.
