Computational Modeling reveals a better understanding of invasive tumor growth and response to therapy of solid malignancies.

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A research team led by Louis Vermeulen from the AMC and Prof. Peter Sloot from the Science Faculty of the UvA revealed how recently discovered Cancer Stem Cells play a crucial role in fundamental properties of tumors. Through the use of novel computational models and laboratory experiments they showed how tumor growth, driven by cancer stem cells, intrinsically orchestrates tumor invasion and increased heterogeneity. The research delivers important insights in therapy response of malignancies to current anticancer therapies and has crucial consequences for the development of successful novel cancer treatments.