SCS colloquium: A Simulation Framework for Investigating in vitro Viral Infection Dynamics and Host Response

Program:

-Speaker: Emiliano Manchini

-Title: “A Simulation Framework for Investigating in vitro Viral Infection Dynamics and Host Response ”

Abstract
Modeling the dynamics of viral infections has been accomplished in the 
past using both mathematical, mainly ODEs, and cellular automata 
models. The focus of these models was to study the dynamics of the 
infection and understand its features but little or no attention was 
paid to the host response to the viral infection or to how the 
distribution of stages of the infection affected gene expression 
measurements. This 2D cellular automata model of an in vitro 
population of cells takes into account spatial characteristics of the 
virus spreading on the Petri dish to simulate the infection dynamics 
and uses the detailed description of the system to predict how its 
status affects gene expression or mRNA measurements. In this paper we 
describe the model characteristics, its validation against a sample 
data set from a SARS infection experiment and present results from a 
Latin Hypercube sampling sensitivity analysis of key parameters.

- "Computational Science 5 minutes"

- Drinks