SCS colloquium: "A cell-based model of extracellular-matrix-driven endothelial cell migration during angiogenesis"

Dear all,

The summer has come and it is time to announce our last SCS colloquium this academic year.
As usual there will be a talk on a research topic. After that prof. dr.  Peter Sloot will reflect on the past academic year
for SCS and have some announcements. We will close the colloquium series with nice food and drinks outside.

Day: Friday 18-06-10
Time: 16:00-17:00
Place: room F0.13

In this colloquium:

-Speakers:
Josephine Daub

Title:
"A cell-based model of extracellular-matrix-driven endothelial cell migration
during angiogenesis"

ABSTRACT
Angiogenesis, the formation of new blood vessels sprouting from existing
ones, occurs in several situations like wound healing, tissue remodeling and
near growing tumors.
Under hypoxic conditions tumors secrete VEGF which activates endothelial
cells (ECs) in nearby vessels, leading to the migration of ECs out of the
vessel and the formation of growing sprouts. Several mechanisms are involved
in angiogenic EC migration, such as chemotaxis, haptotaxis, haptokinesis and
proteolysis of the extracellular matrix (ECM).
In this talk I will present a cell based model of angiogenesis, based on the
Cellular Potts Model (CPM), which includes these mechanisms in simple rules.
Furthermore I will show that this simple set of rules is sufficient to form
sprouts and even branching vascular networks.

- Prof. Dr. Peter Sloot will close the colloquium series.


- Picnic outside in the sun